Polynucleotides for skin, often marketed as "salmon DNA" or PDRN, are fragments of DNA used to support tissue repair. They've surged in aesthetic clinics for hydration, healing, and skin-quality improvements — but the injectable and topical versions are very different things.
What polynucleotides for skin do
Injected polynucleotides are thought to stimulate repair, boost hydration, calm inflammation, and gradually improve skin texture and firmness. The clinical interest is real, particularly for skin quality rather than volume.
Injectable vs topical
- Injectable (in-clinic): where most of the evidence sits, delivered into the skin by a professional.
- Topical serums: convenient, but whether the molecules penetrate meaningfully is far less certain.
Who it suits
People seeking gradual skin-quality improvement — dullness, fine lines, dehydration — under professional care. As with exosomes, topical claims outpace the proof, so anchor your routine in proven basics and treat polynucleotides as a clinic-led option.
FAQ
What are polynucleotides for skin?
DNA fragments (often called PDRN or 'salmon DNA') used to support repair, hydration, and skin quality, mainly via injection.
Do polynucleotide serums work?
The evidence is strongest for injectables. Whether topical serums penetrate enough to work is far less certain.
What is PDRN good for?
Improving skin quality — hydration, texture, and fine lines — rather than adding volume like a filler.
Are polynucleotides safe?
In-clinic use has a growing safety record, but choose a qualified professional and discuss your situation first.